Fats Domino has been played over 10 times on NTS, first on 4 March 2013. Fats Domino's music has been featured on 12 episodes.

Antoine Dominique "Fats" Domino (born February 26, 1928 in New Orleans, Louisiana, died October 24, 2017), was a classic R&B and rock and roll singer, songwriter and pianist. He was the best-selling African-American singer of the 1950s and early 1960s whose congenial, non threatening personality allowed him to succeed despite a period of deep-seated racial segregation. Domino is also a pianist with an individualistic bluesy style showing stride and boogie-woogie influences.

In 1986, he was among the first batch to get inducted into the Rock & Roll Hall Of Fame. "Ain't That A Shame" and "Blueberry Hill" were named part of The Rock & Roll Hall Of Fame's 500 Songs That Shaped Rock & Roll. In 2004, "Blueberry Hill" was named #81 and "Ain't That A Shame" was named #431 on Rolling Stone's Top 500 Songs Of All Time. In 2004, he was named #25 on Rolling Stone's 100 Greatest Artists Of All Time.

In the wake of Domino's rescue from his 9th ward home during 2005's Hurricane Katrina, the Tipitina's Foundation organized a tribute album to the elder artist featuring Robert Plant, Norah Jones, Paul McCartney and numerous other acts that owe a creative debt to this seminal rock n roll pianist.