Major Lazer hosted a guest show on 21 April 2023. Major Lazer has been played on NTS over 70 times, featured on 78 episodes and was first played on 25 February 2013.

Major Lazer is a Jamaican-American electronic dance music and DJ trio, which includes record producer Diplo, and DJs Walshy Fire and Ape Drums. They originate from Kingston, Jamaica, founded in 2008 by Diplo and Switch, with Switch leaving after three years in 2011. He was then replaced by both Jillionaire and Walshy Fire. In June 2019, Jillionaire left the group and was replaced by Ape Drums. Its music spans numerous genres, mixing reggae with dancehall, reggaeton, soca, house and moombahton. Major Lazer has released four full-length albums: Guns Don't Kill People… Lazers Do in 2009, Free the Universe in 2013, Peace Is the Mission in 2015, and Music Is the Weapon in 2020. They have also released six EPs, including Apocalypse Soon in March 2014, which featured vocal contributions from Pharrell Williams of the Neptunes fame and Sean Paul, and Know No Better in 2017, which featured appearances from Camila Cabello, Quavo, Travis Scott, and J Balvin, among others. Major Lazer has also notably produced Reincarnated, the debut reggae album by Snoop Dogg under his "Snoop Lion" persona. In March 2018, Billboard ranked Major Lazer at number five on their 2018 Billboard Dance 100 ranking of dance musicians.