DJ Python has been a regular guest, first appearing on 29 September 2017 and most recently on 8 October 2023. DJ Python has been played on NTS over 190 times, featured on 188 episodes and was first played on 29 January 2016.

Foremost alias of house and reggaeton producer Brian Piñeyro from Queens, New York. He works with deep reggaeton mutations, merging dembow rhythms with the characteristics of deep house.