Run-DMC has been played on NTS over 20 times, featured on 20 episodes and was first played on 23 December 2014.

Run-DMC was an American hip hop group from Hollis, Queens, New York, founded in 1981 by Joseph Simmons, Darryl McDaniels, and Jason Mizell. Run-DMC is widely acknowledged as one of the most influential acts in the history of hip hop culture and one of the most famous hip-hop acts of the 1980s. Along with LL Cool J, The Beastie Boys, and Public Enemy, the group pioneered new school hip-hop music. Run-DMC was the first group in the genre to have a gold album (Run–D.M.C., 1984) and be nominated for a Grammy Award. They were the first to earn a platinum record (King of Rock, 1985), the first to earn a multiplatinum certification (Raising Hell, 1986), the first to have their videos broadcast on MTV, and the first to appear on American Bandstand and the cover of Rolling Stone. Run-DMC was the only hip hop act to perform at Live Aid in 1985.

The group was among the first to highlight the importance of the MC and DJ relationship. In 2004, Rolling Stone ranked them number 48 in their list of the greatest musical artists of all time. In 2007, Run-DMC was named "The Greatest Hip Hop Group of All Time" by MTV.com[6] and "Greatest Hip Hop Artist of All Time" by VH1. In 2009, Run-DMC became the second hip hop group to be inducted into the Rock and Roll Hall of Fame.