Trisomie 21 has been played over 30 times on NTS, first on 24 May 2014. Trisomie 21's music has been featured on 38 episodes.

Trisomie 21 (Literally, a 21st chromosome trisomy, also knows as Down Syndrome), is a group by Philippe Lomprez and Hervé Lomprez, two brothers from Lille, France. Hervé is a Professor of Sounds Technology. Their early music is considered French coldwave (an early cousin of "darkwave"), while their later music electro-pop. Throughout the 80's and 90's, T21 was signed to PIAS Records and their most popular song was "The Last Song".

In 2003, Trisomie 21 remixed "Le Grand Secret" by Indochine which featured Melissa Auf Der Maur from Hole. In 2005 they released "Happy Mystery Child" on Le Marquis Records. This album featured the songs "She Died For Love" and "No Search For Us". They also released the limited edition "A Man Is a Mix", a 3 CD set including "Happy Mystery Child" and 2 discs filled with remixes. Trisomie 21 is currently working on "A Woman Is A Mix", a collection of remixes done by women.